|
KMID : 0385219960060010035
|
|
Korean Journal of Gerontology
1996 Volume.6 No. 1 p.35 ~ p.41
|
|
|
Effects of dietary vitamin E and Selenium Levels on Lipid Peroxidation in Brain of Cadmium Administered Rats
|
|
|
|
|
Abstract
|
|
|
|
The protective effects of dietary vitamin E and selenium on the cellular peroxidative damage induced by Cd administration were investigated in the brain of rats. Male rats of Sprague-Dawley weighing 60±5 g were divided into one control and five cadmium administered groups. Cadmium administered group were classified as Cd0E(vitamin E free diet), Cd40E(vitamin 40 ㎎ of diet), Cd400E(vitamin E 400 ㎎ of diet), Cd400ES(400 ㎎ vitamin E and 0.5 ppm Se/㎏ of diet), Cd0ES(0 ㎎ vitamin E and 0.5 ppm Se/㎏ of diet) according to the level of vitamin E and selenium supplementation. After feeding the diet ad libitum for 2 or 4 weeks, cadmium was injected intra peritoneally to the rats at the level of 2.5 ㎎ cadmium per ㎏ body weight and repeated for three times more with 24 hours of interval. Weight gain and food efficiency ratio of cadmium administered rats were lower than those of control rats. Activities of superoxide dismutase(SOD), glutathione peroxidase(GSH-Px) and glutation S-transferase(GST) in the brain of rats in Cd0E and Cd0E groups were remarkably decreased compared with those of control, while those of rats on dietary vitamin E and selenium were increased significantly compared with those of control TBARS value in brain of cadmium administered groups(Cd0E and Cd0ES) was increased compared with control but the increase was lessened in the brain of rats fed Cd400E and Cd40E diets. On the other hand, Cd400ES group showed no difference compared to control. Two different experimental feeding periods(2 or 4 weeks) did not resulted in any significant differences on enzyme activities or peroxide values. These results indicate that dietary vitamin E and Se could induce antioxidative defense system and relieve peroxidase damage in brain of cadmium administered rats.
|
|
|
KEYWORD
|
|
|
Cadmium toxicity, Vitamin E, Selenium, Lipid peroxidation, Antioxidative defense system
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|